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Leukopenia (from Greek λευκός (leukos), meaning 'white', and πενία (penia), meaning 'deficiency') is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
Neutropenia, a subtype of leukopenia, refers to a decrease in the number of circulating neutrophil granulocytes, the most abundant white blood cells. The terms leukopenia and neutropenia may occasionally be used interchangeably, as the neutrophil count is the most important indicator of infection risk. This should not be confused with agranulocytosis.
An abnormally low count known as leukopenia might indicate bone-marrow failure, a disorder of the liver or spleen, lupus or exposure to radiation.
Recent studies have begun to unravel the cause of this phenomenon, and new research suggests that African Americans with the disease have a unique survival advantage if they have both a low white blood cell count (known as leukopenia) and a genetic variation that is found mainly in persons of African ancestry.
Side effects included pancreatitis and shingles that resulted in discontinuation of 5-acetylsalicylic acid, leukopenia corrected by withholding 6-mercaptopurine and self-resolved hepatitis.
Other findings include disseminated intravascular coagulation, bone marrow aplasia with leukopenia and thrombocytopenia, elevated liver enzyme values, hypocalcemia, hyponatremia and rhabdomyolysis.
To determine whether there is a relationship between the development of elevated aminotransferases, leukopenia or pancreatitis and the TPMT level in patients with IBD.
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